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The Journal of Biological Chemistry’s editors are pleased to announce that the following Papers of the Week have won Best of the Year designations. The Best of the Year articles were selected from the 55 papers published last year. One Best of the Year article was chosen from each of the journal’s TOC groups for its excellence and potential impact on the field. These papers are free to all.

The Role of Mitochondrially Derived ATP in Synaptic Vesicle Recycling

Divya Pathak, Lauren Y. Shields, Bryce A. Mendelsohn, Dominik Haddad, Wei Lin, Akos A. Gerencser, Hwajin Kim, Martin D. Brand, Robert H. Edwards, and Ken Nakamura

The Journal of Biological Chemistry, 290, 22325-22336.
doi: 10.1074/jbc.M115.656405



Spatial Control of Epsin-induced Clathrin Assembly by Membrane Curvature

Sachin S. Holkar, Sukrut C. Kamerkar, and Thomas J. Pucadyil

The Journal of Biological Chemistry, 290, 14267-14276.
doi: 10.1074/jbc.M115.653394



Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation

Anirban Chakraborty, Maki Wakamiya, Tatiana Venkova-Canova, Raj K. Pandita, Leopoldo Aguilera-Aguirre Altaf H. Sarker, Dharmendra Kumar Singh Koa Hosoki Thomas G. Wood Gulshan Sharma, Victor Cardenas, Partha S. Sarkar, Sanjiv Sur, Tej K. Pandita, Istvan Boldogh, and Tapas K. Hazra

The Journal of Biological Chemistry, 290, 24636-24648.
doi: 10.1074/jbc.M115.658146



Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide

Ernesto Cuevasanta , Mike Lange , Jenner Bonanata E. Laura Coitiño Gerardo Ferrer-Sueta Milos R. Filipovic and Beatriz Alvarez

The Journal of Biological Chemistry, 290, 26866-26880.
doi: 10.1074/jbc.M115.672816



Distinct Cellular Assembly Stoichiometry of Polycomb Complexes on Chromatin Revealed by Single-molecule Chromatin Immunoprecipitation Imaging

Roubina Tatavosian, Chao Yu Zhen, Huy Nguyen Duc, Maggie M. Balas, Aaron M. Johnson, and Xiaojun Ren

The Journal of Biological Chemistry, 290, 28038-28054.
doi: 10.1074/jbc.M115.671115



O-GlcNAcomic Profiling Identifies Widespread O-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function

Junfeng Ma, Ting Liu, An-Chi Wei, Partha Banerjee, Brian O'Rourke, and Gerald W. Hart

The Journal of Biological Chemistry, 290, 29141-29153.
doi: 10.1074/jbc.M115.691741



Nuclear Receptor Nr4a2 Promotes Alternative Polarization of Macrophages and Confers Protection in Sepsis

Sahil Mahajan, Ankita Saini, Vemika Chandra, Ravikanth Nanduri, Rashi Kalra, Ella Bhagyaraj, Neeraj Khatri, and Pawan Gupta

The Journal of Biological Chemistry, 290, 18304-18314.
doi: 10.1074/jbc.M115.638064



Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis

Jiangwei Yao, Philip T. Cherian, Matthew W. Frank, and Charles O. Rock

The Journal of Biological Chemistry, 290, 18874-18888.
doi: 10.1074/jbc.M115.657148



Quantitative Analysis of Purine Nucleotides Indicates That Purinosomes Increase de Novo Purine Biosynthesis

Hong Zhao, Christopher R. Chiaro, Limin Zhang, Philip B. Smith, Chung Yu Chan, Anthony M. Pedley, Raymond J. Pugh, Jarrod B. French, Andrew D. Patterson and Stephen J. Benkovic

The Journal of Biological Chemistry, 290, 6705-6713.
doi: 10.1074/jbc.M114.628701



Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592

Chenxiang Tang, Xiaoyun Ji, Li Wu, and Yong Xiong

The Journal of Biological Chemistry, 290, 26352-26359.
doi: 10.1074/jbc.M115.677435



Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization

P. Andrew Chong, Patrick J. Farber, Robert M. Vernon, Rhea P. Hudson, Anthony K. Mittermaier, and Julie D. Forman-Kay

The Journal of Biological Chemistry, 290, 22862-22878.
doi: 10.1074/jbc.M115.641134



Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption

Natalie C. Kegulian, Shalene Sankhagowit, Melania Apostolidou, Sajith A. Jayasinghe, Noah Malmstadt, Peter C. Butler, and Ralf Langen

The Journal of Biological Chemistry, 290, 25782-25793.
doi: 10.1074/jbc.M115.659797



The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic Depression

Tao Li, Yao Tian, Qian Li, Huiying Chen, Huihui Lv, Wei Xie, and Junhai Han

The Journal of Biological Chemistry, 290, 17656-17667.
doi: 10.1074/jbc.M115.644583




Family 46 Carbohydrate-binding Modules Contribute to the Enzymatic Hydrolysis of Xyloglucan and β-1,3–1,4-Glucans through Distinct Mechanisms

Immacolata Venditto, Shabir Najmudin, Ana S. Luís, Luís M. A. Ferreira, Kazuo Sakka, J. Paul Knox, Harry J. Gilbert, and Carlos M. G. A. Fontes

The Journal of Biological Chemistry, 290, 10572-10586.
doi: 10.1074/jbc.M115.637827



Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation

Koji Yamano, Bruno B. Queliconi, Fumika Koyano, Yasushi Saeki, Takatsugu Hirokawa, Keiji Tanaka, and Noriyuki Matsuda

The Journal of Biological Chemistry, 290, 25199-25211.
doi: 10.1074/jbc.M115.671446



Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization

Monika Hartmann, Liseth M. Parra, Anne Ruschel, Christina Lindner, Helen Morrison, Andreas Herrlich, and Peter Herrlich

The Journal of Biological Chemistry, 290, 17041-17054.
doi: 10.1074/jbc.M114.610204

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