一、报告题目

Epigenetic Regulation of Heterochromatin

二、报告嘉宾

李飞, 教授Department of Biology, New York University

三、报告时间

2025年7月14日9:00-11:00

四、报告地点

趵突泉校区教学一号楼一层会议室

五、嘉宾介绍

李飞，纽约大学生物学系教授。李飞教授的研究聚焦于表观遗传学、染色质结构与功能、着丝粒组装与调控，以及异染色质的形成与遗传机制，利用模式生物探索DNA复制、RNA干扰和组蛋白修饰在基因组稳定性与细胞周期调控中的作用。先后主持多项美国国立卫生研究院（NIH）和国家科学基金会（NSF）资助项目，作为第一作者和通讯作者在Cell、Nature、Molecular cell、Nature Communications和PNAS等期刊上发表了一系列论文，多篇被选为封面文章或亮点推荐。先后获得Pew生物医学奖、纽约大学全球研究计划(GRI)研究员、纽约大学提名的埃里森老年学新锐学者候选人等多项荣誉。

六、报告内容

In eukaryotes, DNA is packaged together with histone proteins into an ordered, highly complex chromatin structure. Chromatin exists in two forms: euchromatin and heterochromatin. Euchromatin is typically transcriptionally active and loosely packaged, whereas heterochromatin is the highly condensed and transcriptionally inactive part of the genome. Heterochromatin plays an important role in gene regulation, chromosome segregation and genome stability and has been linked to many diseases, such as cancer, neurological disorders and aging. Heterochromatin is generally composed of repetitive DNA and is characterized by unique epigenetic hallmarks, such as histone H3K9 methylation. We use a combination of approaches, including genetics, biochemistry, cell biology, and structural biology, to define the mechanisms underlying how heterochromatin is organized. Our work has also potential to advance our understanding of human diseases resulting from misregulation of heterochromatin.